Research in the NCC Lab focuses on the neurobiological mechanisms underlying cognitive control.
We define cognitive control as the ability to flexibly adapt behavior to current demands, by promoting task-relevant information and behaviors over temporally-extended periods and in the face of interference or competition.
This ability is central to most higher cognitive functions, and contributes to the unique character of human behavior.
Our goals are to define the neural mechanisms that underlie cognitive control, to understand how these govern behavior, and to use this knowledge to improve our understanding of the relationship between brain and behavior in psychiatric disorders.
Areas of Focus
At the psychological level, our studies focus on attention, inhibition, working memory, and affective and evaluative behavior, all of which are thought to be central to, or to rely critically on cognitive control.
At the biological level, our work focuses on the functions of prefrontal cortex and anterior cinguate, and their regulation by brainstem neuromodulatory systems, such as those using the neurotransmitters dopamine and norepinephrine. Within the clinical domain, our work focuses on disturbances of these systems in schizophrenia.
Our work draws on methods from cognitive psychological, neuroscientific, and psychiatric research, and involves a two-pronged approach:
- The development of neural network-based computer simulation models of performance in cognitive tasks, to explore specific hypotheses about the influence of biological variables on behavior.
- The empirical testing of these hypotheses using standard cognitive tasks, as well as functional neuroimaging techniques.
We use these two approaches in an iterative and interactive way: Models are used to generate empirical predictions, that can be tested in empirical studies. Empirical studies are conducted to both test predictions made by the models and to guide further development.